@article{nokey,

title = {Stem cell-based therapeutic strategies for rotator cuff tendinopathy},

author = {Zetao Wang and Youguo Liao and Canlong Wang and Chenqi Tang and Cailian Fang and Junchao Luo and Hengzhi Liu and Xianan Mo and Zicheng Wang and Lingfang Shen and Junjuan Wang and Xiao Chen and Jianyou Li and Weiliang Shen},

url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470406/},

year  = {2023},

date = {2023-07-23},

urldate = {2023-07-23},

abstract = {Rotator cuff tendinopathy is a common musculoskeletal disorder that imposes significant health and economic burden. Stem cell therapy has brought hope for tendon healing in patients with final stage rotator cuff tendinopathy. Some clinical trials have confirmed the effectiveness of stem cell therapy for rotator cuff tendinopathy, but its application has not been promoted and approved. There are still many issues that should be solved prior to using stem cell therapy in clinical applications. The optimal source and dose of stem cells for rotator cuff tendinopathy should be determined. We also proposed novel prospective approaches that can overcome cell population heterogeneity and standardize patient types for stem cell applications.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Advances in Stem Cell Therapies for Rotator Cuff Injuries},

author = {Hao-Nan Wang and Xiao Rong and Lu-Ming Yang and Wei-Zhong Hua and Guo-Xin Nicorresponding},

url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174670/},

year  = {2022},

date = {2022-05-25},

abstract = {Rotator cuff injury is a common upper extremity musculoskeletal disease that may lead to persistent pain and functional impairment. Despite the clinical outcomes of the surgical procedures being satisfactory, the repair of the rotator cuff remains problematic, such as through failure of healing, adhesion formation, and fatty infiltration. Stem cells have high proliferation, strong paracrine action, and multiple differentiation potential, which promote tendon remodeling and fibrocartilage formation and increase biomechanical strength. Additionally, stem cell-derived extracellular vesicles (EVs) can increase collagen synthesis and inhibit inflammation and adhesion formation by carrying regulatory proteins and microRNAs. Therefore, stem cell-based therapy is a promising therapeutic strategy that has great potential for rotator cuff healing. In this review, we summarize the advances of stem cells and stem cell-derived EVs in rotator cuff repair and highlight the underlying mechanism of stem cells and stem cell-derived EVs and biomaterial delivery systems. Future studies need to explore stem cell therapy in combination with cellular factors, gene therapy, and novel biomaterial delivery systems.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Mesenchymal Stem Cells From Different Sources in Meniscus Repair and Regeneration},

author = {Guocheng Ding and Jianing Du and Xiaoqing Hu and Yingfang},

url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091333/},

year  = {2022},

date = {2022-04-27},

urldate = {2022-04-27},

abstract = {Meniscus damage is a common trauma that often arises from sports injuries or menisci tissue degeneration. Current treatment methods focus on the repair, replacement, and regeneration of the meniscus to restore its original function. The advance of tissue engineering provides a novel approach to restore the unique structure of the meniscus. Recently, mesenchymal stem cells found in tissues including bone marrow, peripheral blood, fat, and articular cavity synovium have shown specific advantages in meniscus repair. Although various studies explore the use of stem cells in repairing meniscal injuries from different sources and demonstrate their potential for chondrogenic differentiation, their meniscal cartilage-forming properties are yet to be systematically compared. Therefore, this review aims to summarize and compare different sources of mesenchymal stem cells for meniscal repair and regeneration.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Stem cells and regenerative medicine in sport science},

author = {Claire E. Stewart},

doi = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589434/},

year  = {2021},

date = {2021-08-27},

abstract = {The estimated cost of acute injuries in college-level sports in the USA is ∼1.5 billion dollars annually, without considering the cost of follow-up rehabilitation. In addition to this huge financial burden, sports injuries may be career-ending for some athletes without appropriate diagnosis and relevant interventions. With a growing number of females participating in contact-based and pivoting sports, middle-aged individuals returning to sports,s and natural injuries of aging all increasing, such costs and negative implications for quality of life will expand. For those injuries that cannot be predicted and prevented, there is a real need to optimize repair, recovery, and function post-injury in the sporting and clinical worlds. The 21st century has seen rapid growth in regenerative medicine for sporting injuries to progress recovery and facilitate return to sport. Such interventions harness knowledge relating to stem cells as a potential for injury repair. While the field is rapidly growing, consideration beyond the stem cells to the factors they secrete should be considered in developing practical, affordable treatments.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Stem cell therapies in tendon-bone healing},

author = {Yue Xu and Wan-Xia Zhang and Li-Na Wang and Yue-Qing Ming and Yu-Lin Li and Guo-Xin Ni},

url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316867/},

year  = {2021},

date = {2021-07-26},

urldate = {2021-07-26},

abstract = {Tendon-bone insertion injuries such as rotator cuff and anterior cruciate ligament injuries are currently highly common and severe. The key method of treating this kind of injury is the reconstruction operation. The success of this reconstructive process depends on the ability of the graft to incorporate into the bone. Recently, there has been substantial discussion about how to enhance the integration of tendon and bone through biological methods. Stem cells like bone marrow mesenchymal stem cells (MSCs), tendon stem/progenitor cells, synovium-derived MSCs, adipose-derived stem cells, or periosteum-derived periosteal stem cells can self-regenerate and potentially differentiate into different cell types, which have been widely used in tissue repair and regeneration. Thus, we concentrate in this review on the current circumstances of tendon-bone healing using stem cell therapy.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Emerging Applications of Stem Cell and Regenerative Medicine to Sports Injuries},

author = {David A. Ajibadea and Danica D. Vance and Joshua M. Harea and Lee D. Kaplanand Bryson P. Lesniak},

url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555618/},

year  = {2014},

date = {2014-02-02},

abstract = {Cell-based therapies and regenerative medicine offer safe and potentially efficacious treatment for sports-related musculoskeletal injuries. Basic science and preclinical studies that support the possibility of enhanced recovery from sports injuries using cell-based therapies are accumulating; however, more clinical evidence is necessary to define the indications and parameters for their use. Accordingly, exposing patients to cell-based therapies could confer an unacceptable risk profile with minimal or no benefit. Continued clinical testing with animal models and clinical trials is necessary to determine the relative risks and benefits as well as the indications and methodology of treatment.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}